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Current Drug Delivery

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ISSN (Print): 1567-2018
ISSN (Online): 1875-5704

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Mini-Review Article

Preparation, Characterization and Drug Delivery Research of γ-Polyglutamic Acid Nanoparticles: A Review

Author(s): Zhihan Liu, Yan He and Xia Ma*

Volume 21, Issue 6, 2024

Published on: 13 January, 2023

Page: [795 - 806] Pages: 12

DOI: 10.2174/1567201820666230102140450

Price: $65

Abstract

γ-Polyglutamic acid is a kind of biomaterial and environmentally friendly polymer material with the characteristics of water solubility and good biocompatibility. It has a wide range of applications in medicine, food, cosmetics and other fields. This article reviews the preparation, characterization and medical applications of γ-polyglutamic acid nanoparticles. Nanoparticles prepared by using γ- polyglutamic acid not only had the traditional advantages of enhancing drug stability and slow-release effect, but also were simple to prepare without any biological toxicity. The current methods of nanoparticle preparation mainly include the ion gel method and solvent exchange method, which use the total electrostatic force, van der Waals force, hydrophobic interaction force and hydrogen bond force between molecules to embed materials with different characteristics. At present, there are more and more studies on the use of γ-polyglutamic acid to encapsulate drugs, and the research on the mechanism of its encapsulation and sustained release has gradually matured. The development and application of polyglutamic acid nanoparticles have broad prospects.

Keywords: γ-Polyglutamic acid, nanoparticles, drug delivery, slow release, anticancer, antimicrobial, responsive controllable release.

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