Title:The Association of LDH Expression and Delayed Cerebral Ischemia in
Patients with Aneurysmal Subarachnoid Hemorrhage: Possible Involvement
of Cerebral Blood Perfusion
Volume: 20
Issue: 1
Author(s): Yingwen Wang, Shuang Tang, Xiaomin Yang, Yunchuan Cao, Xiaoguo Li, Rui Xu, Jin Yan, Zongduo Guo, Xiaochuan Sun*Yue Wu*
Affiliation:
- Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
- Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Keywords:
Aneurysmal subarachnoid hemorrhage, serum lactate dehydrogenase level, cerebral blood flow, delayed cerebral ischemia, ROC, CTP, EEG.
Abstract:
Background and Purpose: Several pieces of evidence suggest that serum lactate hydrogenase
(LDH) level is associated with the pathological process of delayed cerebral ischemia (DCI)
after aneurysmal subarachnoid hemorrhage (aSAH). This research aimed to investigate the associations
of serum LDH level with the occurrence of DCI in aSAH patients.
Methods: A total of 122 patients diagnosed with aSAH within 72h of onset were retrospectively
enrolled. The serum levels of LDH between 7:00-8:00 am on day 1, day 3 and day 7, patients’ demographics,
and clinical features were collected. Computed tomography perfusion was performed
within 7 days after aSAH. The occurrence of DCI was recorded during the hospitalization.
Results: Among all the enrolled patients, 43 (35.2%) developed DCI during hospitalization. Patients
occurred DCI were always accompanied by more serious clinical features and found with higher
serum LDH levels. LDH levels on day 3 and day 7 after onset were independently associated with
the occurrence of DCI and showed high predictive value according to the receiver operating characteristic
(ROC) curve. Moreover, there was a strong correlation between LDH and mean cerebral
blood flow, transit time, and mean time to peak.
Conclusion: Serum LDH level on day 3 and day 7 may be a valuable, convenient, and rapid predictive
indicator for the occurrence of DCI in aSAH patients.
