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CNS & Neurological Disorders - Drug Targets

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ISSN (Online): 1996-3181

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Review Article

The Neuroprotective Role of BCG Vaccine in Movement Disorders: A Review

Author(s): Narhari Gangaram Yedke and Puneet Kumar*

Volume 23, Issue 1, 2024

Published on: 13 January, 2023

Page: [30 - 38] Pages: 9

DOI: 10.2174/1871527322666221223142813

Price: $65

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Abstract

Bacillus Calmette-Guérin (BCG) is the first developed vaccine to prevent tuberculosis (TB) and is the world's most widely used vaccine. It has a reconcilable defense in opposition to tuberculosis, meningitis, and miliary disease in children but changeable protection against pulmonary TB. Immune activation is responsible for regulating neural development by activating it. The effect of the BCG vaccine on neuronal disorders due to subordinate immune provocation is useful. BCG vaccine can prevent neuronal degeneration in different neurological disorders by provoking auto-reactive T-cells. In the case of TB, CD4+ T-cells effectively protect the immune response by protecting the central defense. Because of the preceding fact, BCG induces protection by creating precise T-cells like CD4+ T-cells and CD8+ T-cells. Hence, vaccination-induced protection generates specific T-cells and CD4+ T-cells, and CD8+ T-cells. The BCG vaccine may have an essential effect on motor disorders and play a crucial role in neuroprotective management. The present review describes how the BCG vaccine might be interrelated with motor disorders and play a key role in such diseases.

Keywords: BCG vaccine, neuroprotection, movement disorders, neuroinflammation, autoimmunity, PD.

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