Title:The Evolution of Pancreatic Islet Function in a Diabetic Patient after
Pancreatic Neuroendocrine Neoplasm Surgery: A Case Report
Volume: 23
Issue: 7
Author(s): Song Wen, Junhong Pan, Congying Liu, Xinlu Yuan, Congcong Wang, Qinghua You, Xinjiang Liu and Ligang Zhou*
Affiliation:
- Department of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai, 201399, China
- Shanghai Key Laboratory of Vascular Lesions Regulation
and Remodeling, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, 201399, China
Keywords:
Pancreatic, neuroendocrine, neoplasms, tumorectomy, β-cell function, type 2 diabetes, HOMA-IR.
Abstract:
Background: Pancreatic neuroendocrine neoplasms (pNENs) are rare primary tumors
of the pancreas. Although these tumors are heterogeneous and can be classified as functional or
non-functional according to pancreatic endocrine biomarkers, the more prevalent type is non-functional
pNENs with endocrine differentiation but with non-specific symptoms and often late diagnoses.
The treatment option for patients often involves surgical management, but the reported outcomes,
especially on insulin secretion change and the trend of diabetes in these patients, varied to
date. Hence, the purpose of this clinical report is to study the functional change of pancreatic β-
cell corresponding to the mass of tumorectomy of pNEN in a diabetic patient.
Case Presentation: We reported that a 39-year-old man with diabetes was found complicated with
neuroendocrine neoplasm. He was admitted to the General Surgery of our hospital for further examination
and therapy. The patient received a pancreatectomy + splenectomy + lymphadenectomy
on the pancreatic body and tail. We analyzed the pancreatic mass change and performed Oral Glucose
Tolerance Test (OGTT) before and after the surgery to evaluate the function of the pancreas.
Conclusion: This case may provide us a reference to predict the extent of islet function loss before
the pancreatectomy, and apply personalized hypoglycemic therapy after surgery in these patients.
