Title:Effects of Coffee Supplementation on Homocysteine and Leptin Levels: A Systematic Review and Meta-analysis of Clinical Trials
Volume: 29
Issue: 1
Author(s): Luis E. Simental-Mendía*, Mario Simental-Mendía and Mayela Ríos-Mier
Affiliation:
- Unidad de Investigación Biomédica, Instituto Mexicano del Seguro Social, Delegación Durango, México.
Keywords:
Coffee, homocysteine, leptin, meta-analysis, antioxidant foods, beverages, cardiovascular risk factors.
Abstract:
Background: It has been reported that the consumption of antioxidant foods and beverages may benefit
the development of cardiovascular risk factors. However, the impact of coffee consumption on some of these
factors, such as homocysteine and leptin is controversial. Some clinical trials have suggested that coffee administration
increases plasma total homocysteine levels, while others have found no significant changes in
leptin concentrations.
Objective: This study aimed to assess the effects of coffee supplementation on homocysteine and leptin concentrations
in a meta-analysis of clinical trials.
Methods: PubMed, Web of Science, Scopus, ClinicalTrials.gov, and Google Scholar databases were searched
from inception to September 29, 2021. A fixed-effects model and the generic inverse variance weighting
method were used for meta-analysis.
Results: The meta-analysis demonstrated that coffee administration significantly increases homocysteine levels
(WMD: 0.55 μmol/L, 95% CI: 0.17, 0.93, p = 0.005, I2 = 0%) but has no significant changes in leptin concentrations
(WMD: 1.34 ng/mL, 95% CI: -0.78, 3.45, p = 0.21, I2 = 0%). Additionally, the sensitivity analysis was robust
for both homocysteine and leptin levels.
Conclusion: The results of the present meta-analysis revealed that coffee supplementation raises serum homocysteine
concentrations but has no effect on circulating leptin levels.
