Title:Levothyroxine Sodium - Thyroid Hormone Replacement Therapy
for Hypothyroidism: A Review of Patent Literature
Volume: 17
Issue: 3
Author(s): Uddeshya Upadhyay*, Pratik Ashwinbhai Vora, Rakesh Patel and Bijal Prajapati
Affiliation:
- Department of Pharmaceutics, Faculty of Pharmacy, Parul University, Vadodara, India
Keywords:
Composition, hypothyroidism, levothyroxine, thyroid, patent, pseudoscientists.
Abstract:
Background: Levothyroxine Sodium is a thyroid hormone replacement therapy
for Hypothyroidism. Levothyroxine Sodium is approved to treat Hypothyroidisim, to suppress
thyroid hormone release from cancerous thyroid nodules, and to prevent the growth
of goiters. In addition, it is also used to treat conditions such as myxedema, cretinism, and
obesity.
Objective: This assessment highlights the overview of the recent patents of Levothyroxine
Sodium. This review includes patents grouped in sections like product patents, process patents,
and composition-related patents, along with the treatment methodology. The objective
of this article is to impel pseudoscientists to all existing patents in a solitary place.
Methods: Data were gathered from various internet-based resources, including Patentscope
® (WIPO), Worldwide Espacenet® (EPO), Google Patents, and InPASS (Indian
patent database).
Results: Several new processes and composition-related patents of Levothyroxine Sodium
have been reported. Further, due to the problem of photosensitivity, oxidation during development,
and stability of Levothyroxine Sodium formulation, several excipients are tried
in these patents to stabilize the same. However, the formulation of Levothyroxine Sodium
with better characteristics needs to be developed.
Conclusion: Extensive exposure has been carried out towards various processes for the
preparation of Levothyroxine Sodium and the composition of the same. This sort of dynamic
exploration will clear the path for many generic players, which will lead to the reduction
of the expense of the composition and accordingly enhance global health care at a
less expensive cost.
