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Current Neuropharmacology

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ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

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Review Article

KCa-Related Neurological Disorders: Phenotypic Spectrum and Therapeutic Indications

Author(s): Aqeela Zahra, Ru Liu, Wenzhe Han, Hui Meng, Qun Wang, YunFu Wang, Susan L. Campbell and Jianping Wu*

Volume 21, Issue 7, 2023

Published on: 19 December, 2022

Page: [1504 - 1518] Pages: 15

DOI: 10.2174/1570159X21666221208091805

Price: $65

Open Access Journals Promotions 2
Abstract

Although potassium channelopathies have been linked to a wide range of neurological conditions, the underlying pathogenic mechanism is not always clear, and a systematic summary of clinical manifestation is absent. Several neurological disorders have been associated with alterations of calcium-activated potassium channels (KCa channels), such as loss- or gain-of-function mutations, post-transcriptional modification, etc. Here, we outlined the current understanding of the molecular and cellular properties of three subtypes of KCa channels, including big conductance KCa channels (BK), small conductance KCa channels (SK), and the intermediate conductance KCa channels (IK). Next, we comprehensively reviewed the loss- or gain-of-function mutations of each KCa channel and described the corresponding mutation sites in specific diseases to broaden the phenotypic-genotypic spectrum of KCa-related neurological disorders. Moreover, we reviewed the current pharmaceutical strategies targeting KCa channels in KCa-related neurological disorders to provide new directions for drug discovery in anti-seizure medication.

Keywords: Potassium channels, channelopathies, modulators, pharmacology, epilepsy, action potential.

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