Title:LINC00665: A Promising Biomarker in Gastrointestinal Tumors
Volume: 24
Issue: 1
Author(s): Mengping Yuan, Yuyang Gu, Jiawen Chen, Yibin Jiang, Jing Qian*Shuguang Cao*
Affiliation:
- School of Medicine, Huzhou University, Huzhou, 313000, PR China
- Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, Huzhou University, Huzhou, 313000, PR China
- Department of Gastroenterology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, PR China.
Keywords:
LINC00665, gastrointestinal tumors, biomarker, diagnosis, prognosis, therapy, CeRNA.
Abstract: An increasing volume of studies has reported that long non-codingRNAs
(lncRNAs) are involved in the carcinogenesis of many different cancers. Especially in
gastrointestinal tumors, lncRNAs are found to participate in various physiological and
pathological processes. LncRNAs can regulate gene expression at multiple levels,
including transcriptional, post-transcription, translational, and post-translational levels.
Long intergenic non-protein coding RNA 665(LINC00665), a novel cancer-related
lncRNA, is frequently dysregulated in multiple gastrointestinal tumors, including gastric
and colorectal cancers, hepatocellular carcinoma, and so on. In this review, we
analyzed the expression and prognostic value of LINC00665 in human gastrointestinal
tumors, systematically summarized the current literature about the clinical significance
of this lncRNA, and explored the regulatory mechanisms of LINC00665 as a competing
endogenous RNA (ceRNA) in tumor progression. Consequently, we concluded
that LINC00665 might act as a prognostic biomarker and a potential target for gastrointestinal
tumor diagnosis and treatment.
