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Current Neuropharmacology

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ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

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Commentary

Bidirectional Communication Between Microglia and Astrocytes in Neuroinflammation

Author(s): Anup Bhusal, Ruqayya Afridi, Won-Ha Lee and Kyoungho Suk*

Volume 21, Issue 10, 2023

Published on: 06 January, 2023

Page: [2020 - 2029] Pages: 10

DOI: 10.2174/1570159X21666221129121715

Abstract

Neuroinflammation is a common feature of diverse nervous system pathologies. In many instances, it begins at an early stage of the disease, paving the way for further exacerbations. The main drivers of neuroinflammation are brain-resident glial cells, such as microglia and astrocytes. Microglia are the primary responders to any insult to the brain parenchyma, translating the signals into diverse molecules. These molecules derived from microglia can regulate the stimuli-dependent reactivity of astrocytes. Once activated, astrocytes in turn, can control microglia phenotypes. Recent evidence indicates that the crosstalk between these glial cells plays an important role in delaying or accelerating neuroinflammation and overall disease progression. To date, various molecules have been recognized as key mediators of the bidirectional communication between microglia and astrocytes. The current review aims to discuss the novel molecules identified recently, which play a critical role in interglial crosstalk, highlighting their therapeutic potential.

Keywords: Microglia, astrocytes, crosstalk, neuroinflammation, glia, central nervous system.

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Graphical Abstract

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