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CNS & Neurological Disorders - Drug Targets

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ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

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Review Article

Pharmacological and Pathological Relevance of S100 Proteins in Neurological Disorders

Author(s): Deepali Goswami, Urati Anuradha, Anok Angati, Nisha Kumari and Rakesh Kumar Singh*

Volume 22, Issue 10, 2023

Published on: 13 January, 2023

Page: [1403 - 1416] Pages: 14

DOI: 10.2174/1871527322666221128160653

Price: $65

Abstract

The S100 protein is one of the calcium-binding proteins associated with Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. S100 proteins are expressed in the central nervous system by oligodendrocytes, astrocytes and neurons during both normal and disease conditions. Although amyloid-beta aggregation and hyperphosphorylated tau plaques are the main pathological hallmarks of Alzheimer’s disease, the S100 protein family is closely associated with neuroinflammation in several neurodegenerative disorders, such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis in addition to various types of cancer and other brain diseases. This review aims to present the key role of S100 proteins and their different relevant isoforms, along with the various approaches used for the regulation of these proteins in several neurodegenerative disorders.

Keywords: S100 protein, neurodegenerative disease, brain biomarker, Alzheimer’s disease, neuroinflammation, CNS.

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Graphical Abstract

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