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Systematic Review Article

水飞蓟素/水飞蓟宾对放射治疗毒性的辐射防护潜力:临床和实验研究的系统综述

卷 30, 期 33, 2023

发表于: 28 December, 2022

页: [3775 - 3797] 页: 23

弟呕挨: 10.2174/0929867330666221124155339

价格: $65

摘要

背景：虽然放射治疗是主要的癌症治疗方式之一，但在治疗期间将健康器官/组织暴露于电离辐射可导致不同的不良反应。在这方面，已经证明使用辐射防护剂可以减轻电离辐射引起的毒性。 目的：本研究旨在综述水飞蓟素/水飞蓟宾素在预防/减少电离辐射对健康细胞/组织的不良影响中的辐射防护潜力。 方法：基于PRISMA指南，对截至2022年4月Web of Science、PubMed、Scopus等不同数据库中“水飞蓟素/水飞蓟宾素治疗放射诱导毒性的潜在保护作用”的相关文献进行了全面系统的检索。根据本研究的纳入和排除标准，获得并筛选了455篇文章。最后，19篇论文被纳入本系统综述。 结果：研究结果显示，与对照组相比，电离辐射治疗组的存活率和体重都有所下降。研究还发现，辐射会对皮肤、消化系统、血液系统、淋巴系统、呼吸系统、生殖系统和泌尿系统产生轻微到严重的不良影响。然而，在大多数情况下，水飞蓟素/水飞蓟宾可以减轻电离辐射引起的不良反应。该中草药通过抗氧化、抗凋亡、抗炎等机制发挥辐射防护作用。 结论：本系统综述结果显示，水飞蓟素/水飞蓟宾与放疗联合治疗可减轻健康细胞/组织中放疗引起的不良反应。

关键词: 抗癌、放疗、水飞蓟素、水飞蓟宾、抗氧化、抗凋亡、抗炎。

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