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Current Neuropharmacology

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ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

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Review Article

The Diverse Network of Brain Histamine in Feeding: Dissect its Functions in a Circuit-Specific Way

Author(s): Lingyu Xu, Wenkai Lin, Yanrong Zheng, Yi Wang and Zhong Chen*

Volume 22, Issue 2, 2024

Published on: 22 March, 2023

Page: [241 - 259] Pages: 19

DOI: 10.2174/1570159X21666221117153755

Price: $65

Open Access Journals Promotions 2
Abstract

Feeding is an intrinsic and important behavior regulated by complex molecular, cellular and circuit-level mechanisms, one of which is the brain histaminergic network. In the past decades, many studies have provided a foundation of knowledge about the relationship between feeding and histamine receptors, which are deemed to have therapeutic potential but are not successful in treating feeding- related diseases. Indeed, the histaminergic circuits underlying feeding are poorly understood and characterized. This review describes current knowledge of histamine in feeding at the receptor level. Further, we provide insight into putative histamine-involved feeding circuits based on the classic feeding circuits. Understanding the histaminergic network in a circuit-specific way may be therapeutically relevant for increasing the drug specificity and precise treatment in feeding-related diseases.

Keywords: Histamine, histamine receptor ligands, neural circuit, feeding, drug target, brain histaminergic network.

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