Title:Serum Uric Acid Levels Are Associated With Macula Microvasculature
Changes In Hypertensive White Matter Hyperintensity Patients
Volume: 20
Issue: 1
Author(s): Ruili Wei, Jianyang Xie, Fangxia Meng, Fangping He, Jiang Liu, Yitian Zhao*Hui Liang*
Affiliation:
- Cixi Institute of Biomedical Engineering, Ningbo Institute of Materials Technology and Engineering,
Chinese Academy of Sciences, Ningbo, China
- Department of Neurology, First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou
310003, China
Keywords:
Serum uric acid, macula, white matter hyperintensity, optical coherence tomography, Fazekas scale, microvasculature.
Abstract:
Purpose: To characterize the macula microvasculature using fractal dimension (FD) in
hypertensive white matter hyperintensity (WMH) participants and explore the association between
the microvascular changes and serum uric acid levels.
Methods: Thirty-eight WMH participants were dementia and stroke-free, and 37 healthy controls
were enrolled. Optical coherence tomographic angiography (OCTA) was used to image the superficial
vascular complex (SVC), deep vascular complex (DVC), and inner vascular complex (IVC) in a
2.5-mm diameter concentric circle (excluding the foveal avascular zone FAZ). A commercial algorithm
was used to quantify the complexity and density of the three capillary layers by fractal analysis.
Results: WMH participants showed significantly lower FD value in the SVC (P = 0.002), DVC (P <
0.001) and IVC (P = 0.012) macula microvasculature compared with control group. After adjusting
for risk factors (hypertension, diabetes, age and gender) SVC (P = 0.035) and IVC (P = 0.030) significantly
correlated with serum uric acid.
Conclusion: Serum uric acid levels are associated with microvascular changes in WMH. Fractal
dimension based on OCTA imaging could help quantitatively characterize the macula microvasculature
changes in WMH and may be a potential screening tool to detect serum uric acid level changes.
