Title:Effect of Fibroblast Growth Factor-21 Molecule on Coronary Collateral
Development
Volume: 27
Issue: 14
Author(s): Halil Fedai*Mustafa Begenc Tascanov
Affiliation:
- Clinic of Cardiology, Sanliurfa Training and Research Hospital, Sanliurfa, Turkey
Keywords:
Fibroblast growth factor-21, coronary collateral, coronary artery disease, angiogenesis, coronary angiography, pathophysiology.
Abstract:
Background: Collateral arteries provide an alternative source to the myocardium resulting
from ischemia due to occlusive coronary artery disease and may help preserve myocardial
function in the case of coronary artery disease (CAD). Although collateral development is so important,
its pathophysiology has not been fully elucidated. Till now, no study has investigated the
relationship between Fibroblast growth factor-21(FGF-21) and coronary collateral.
Objective: This study aims to investigate the pathophysiology of coronary collateral development.
Methods: In our study, which we planned as a case-control, 60 consecutive patients with ≥90 stenosis
in at least one large coronary artery as a result of coronary angiography (CAG) and 30 patients
with normal coronary angiography were included in the study cross-sectional. Demographic,
echocardiographic and laboratory data were recorded. Coronary collateral circulation was evaluated
using the Rentrop-Cohen method. FGF-21 levels were measured in all individuals.
Results: In the analysis, no significant difference was observed between the two groups in basic
biochemical parameters other than HDL (p>0.05 for all). FGF-21 level was statistically significantly
higher in the patient group compared to the control group (p: 0.003). Also, the FGF-21 level was
found to be statistically significantly higher in the good collateral circulation group than the poor
(p:0.006). Univariate and multivariate logistic regression analysis was performed to predict the
presence of collateral. We found that FGF-21(p=0.006), and C-reactive protein (p=0.020) predicted
the presence of collateral independently.
Conclusion: Collateral formation and cardiac prognosis are closely related. Our study is the first to
investigate the relationship between collateral formation and FGF-21. Our study showed that the
FGF-21 level is an independent predictor of collateral formation. In addition, there was a significant
difference between bad and good collateral formation regarding FGF-21 levels.
