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Current Pediatric Reviews

Editor-in-Chief

ISSN (Print): 1573-3963
ISSN (Online): 1875-6336

Mini-Review Article

Impact of “Long Covid” on Children: Global and Hong Kong Perspectives

Author(s): Kam Lun Ellis Hon*, Alexander K.C. Leung, Karen Ka Yan Leung and Alex H.C. Wong

Volume 20, Issue 1, 2024

Published on: 28 December, 2022

Page: [59 - 65] Pages: 7

DOI: 10.2174/1573396319666221021154949

Price: $65

Open Access Journals Promotions 2
Abstract

Background: The coronavirus disease (COVID-19) pandemic spares no nation or city, and the virus is responsible for the escalating incidence and mortality worldwide.

Objective: This article reviews the impact of “Long Covid” on Children.

Methods: A PubMed search was conducted in December 2021 in Clinical Queries using the key terms "COVID-19" OR “long COVID”. The search was restricted to children and adolescent aged < 18 years and English literature.

Results: Many large-scale studies have provided strong scientific evidence as to the detrimental and irreversible sequelae of COVID-19 on the health, psychology, and development of affected children. Many insights into managing this disease can be obtained from comparing the management of influenza. COVID-19 is generally a mild respiratory disease in children. Several syndromes, such as multisystem inflammatory syndrome in children (MIS-C) and COVID toe, are probably not specific to SARS-CoV-2. “Long COVID”, or the long-term effects of SARS-CoV-2 infection, or the prolonged isolation and containment strategies on education and psychosocial influences on children associated with the pandemic, are significant.

Conclusion: Healthcare providers must be aware of the potential effects of quarantine on children's mental health. More importantly, healthcare providers must appreciate the importance of the decisions and actions made by governments, non-governmental organizations, the community, schools, and parents in reducing the possible effects of this situation. Multifaceted age-specific and developmentally appropriate strategies must be adopted by healthcare authorities to lessen the negative impact of quarantine on the psychological well-being of children.

Keywords: COVID-19, coronavirus, SARS-CoV-2, long COVID, mortality, influenza.

Graphical Abstract
[1]
Hon KL, Leung KKY. Severe acute respiratory symptoms and suspected SARS again 2020. Hong Kong Med J 2020; 26(1): 78-9.
[http://dx.doi.org/10.12809/hkmj208375] [PMID: 32077866]
[2]
Cheng FK. The myth of the para-lockdown to fight COVID-19 in Hong Kong. Int J Travel Med Glob Health 2021; 9(4): 194-5.
[http://dx.doi.org/10.34172/ijtmgh.2021.32]
[3]
Wikipedia. COVID-19 pandemic in Hong Kong. 2022. Available from: https://en.wikipedia.org/wiki/COVID-19_pandemic_in_Hong_Kong#Fourth_wave (Accessed on: 2022 Jul 9).
[4]
Kunno J, Supawattanabodee B, Sumanasrethakul C, Wiriyasivaj B, Kuratong S, Kaewchandee C. Comparison of different waves during the COVID-19 pandemic: retrospective descriptive study in thailand. Adv Prev Med 2021; 2021: 1-8.
[http://dx.doi.org/10.1155/2021/5807056] [PMID: 34659835]
[5]
Iftimie S, López-Azcona AF, Vallverdú I, et al. First and second waves of coronavirus disease-19: A comparative study in hospitalized patients in Reus, Spain. PLoS One 2021; 16(3): e0248029.
[http://dx.doi.org/10.1371/journal.pone.0248029] [PMID: 33788866]
[6]
Seong H, Hyun HJ, Yun JG, et al. Comparison of the second and third waves of the COVID-19 pandemic in South Korea: Importance of early public health intervention. Int J Infect Dis 2021; 104: 742-5.
[http://dx.doi.org/10.1016/j.ijid.2021.02.004] [PMID: 33556610]
[7]
Godman B, Haque M, Islam S, et al. Rapid assessment of price instability and paucity of medicines and protection for COVID-19 across Asia: Findings and public health implications for the future. Front Public Health 2020; 8: 585832.
[8]
Farooq HZ, Davies E, Brown B, et al. Real-world SARS CoV-2 testing in Northern England during the first wave of the COVID-19 pandemic. J Infect 2021; 83(1): 84-91.
[http://dx.doi.org/10.1016/j.jinf.2021.04.013] [PMID: 33892016]
[9]
Cherednik I. Modeling the waves of Covid-19. Acta Biotheor 2022; 70(1): 8.
[http://dx.doi.org/10.1007/s10441-021-09428-w] [PMID: 34958426]
[10]
Cuadros DF, Moreno CM, Musuka G, Miller FD, Coule P, MacKinnon NJ. Association between vaccination coverage disparity and the dynamics of the COVID-19 delta and omicron waves in the US. Front Med (Lausanne) 2022; 9: 898101.
[http://dx.doi.org/10.3389/fmed.2022.898101] [PMID: 35775002]
[11]
Chua GT, Wong JSC, Lam I, et al. Clinical characteristics and transmission of COVID-19 in children and youths during 3 waves of outbreaks in Hong Kong. JAMA Netw Open 2021; 4(5): e218824.
[http://dx.doi.org/10.1001/jamanetworkopen.2021.8824] [PMID: 33938934]
[12]
Song X, Delaney M, Shah RK, Campos JM, Wessel DL, DeBiasi RL. Comparison of clinical features of COVID-19 vs seasonal influenza A and B in US children. JAMA Netw Open 2020; 3(9): e2020495.
[http://dx.doi.org/10.1001/jamanetworkopen.2020.20495] [PMID: 32897374]
[13]
Hon KL, Leung KKY, Hui WF, Ng DKK. Applying lessons from influenza pandemics to the COVID‐19 pandemic. Pediatr Pulmonol 2021; 56(9): 3071-4.
[http://dx.doi.org/10.1002/ppul.25571] [PMID: 34288587]
[14]
Hon KL, Leung KKY. From influenza to COVID‐19 vaccinations: Counselling anxious parents about deaths following influenza immunizations in Korea. Pediatr Pulmonol 2021; 56(6): 1779-81.
[http://dx.doi.org/10.1002/ppul.25260] [PMID: 33765351]
[15]
Hoang A, Chorath K, Moreira A, et al. COVID-19 in 7780 pediatric patients: A systematic review. EClin Med 2020; 24: 100433.
[http://dx.doi.org/10.1016/j.eclinm.2020.100433] [PMID: 32766542]
[16]
Jeng MJ. Coronavirus disease 2019 in children: Current status. J Chin Med Assoc 2020; 83(6): 527-33.
[http://dx.doi.org/10.1097/JCMA.0000000000000323] [PMID: 32502117]
[17]
Choi SH, Kim HW, Kang JM, Kim DH, Cho EY. Epidemiology and clinical features of coronavirus disease 2019 in children. Clin Exper Pediatr 2020; 63(4): 125-32.
[http://dx.doi.org/10.3345/cep.2020.00535] [PMID: 32252139]
[18]
Koschitzky M, Oyola RR, Lee-Wong M, Abittan B, Silverberg N. Pediatric COVID toes and fingers. Clin Dermatol 2021; 39(1): 84-91.
[http://dx.doi.org/10.1016/j.clindermatol.2020.12.016] [PMID: 33972057]
[19]
Ahmed M, Advani S, Moreira A, et al. Multisystem inflammatory syndrome in children: A systematic review. EClin Med 2020; 26(Sep): 100527.
[http://dx.doi.org/10.1016/j.eclinm.2020.100527] [PMID: 32923992]
[20]
Leung KKY, Hon KL, Wang MHT, Ng DKK, Ip P. Paediatric multisystem inflammatory syndrome and COVID-19: Another novel syndrome? Hong Kong Med J 2021; 27(2): 161-2.
[http://dx.doi.org/10.12809/hkmj208681]
[21]
Rajapakse N, Dixit D. Human and novel coronavirus infections in children: A review. Paediatr Int Child Health 2021; 41(1): 36-55.
[http://dx.doi.org/10.1080/20469047.2020.1781356] [PMID: 32584199]
[22]
Sharma C, Ganigara M, Galeotti C, et al. Multisystem inflammatory syndrome in children and Kawasaki disease: A critical comparison. Nat Rev Rheumatol 2021; 17(12): 731-48.
[http://dx.doi.org/10.1038/s41584-021-00709-9] [PMID: 34716418]
[23]
Walker DM, Tolentino VR. COVID-19: The impact on pediatric emergency care. Pediatr Emerg Med Pract 2020; 17(Suppl 6-1): 1-27.
[24]
Rowley AH. Understanding SARS-CoV-2-related multisystem inflammatory syndrome in children. Nat Rev Immunol 2020; 20(8): 453-4.
[http://dx.doi.org/10.1038/s41577-020-0367-5] [PMID: 32546853]
[25]
Chua GT, Xiong X, Choi EH, et al. COVID-19 in children across three Asian cosmopolitan regions. Emerg Microbes Infect 2020; 9(1): 2588-96.
[http://dx.doi.org/10.1080/22221751.2020.1846462] [PMID: 33138739]
[26]
Shen K, Yang Y, Wang T, et al. Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: Experts’ consensus statement. World J Pediatr 2020.
[27]
Lu X, Zhang L, Du H, et al. SARS-CoV-2 infection in children. N Engl J Med 2020; 382: 1663-5.
[http://dx.doi.org/10.1056/NEJMc2005073]
[28]
Dong Y, Mo X, Hu Y, et al. Epidemiology of COVID-19 Among Children in China. Pediatrics 2020; 145(6): e20200702.
[http://dx.doi.org/10.1542/peds.2020-0702] [PMID: 32179660]
[29]
Zimmermann P, Curtis N. Coronavirus infections in children including COVID-19. Pediatr Infect Dis J 2020; 39(5): 355-68.
[http://dx.doi.org/10.1097/INF.0000000000002660] [PMID: 32310621]
[30]
Chua GT, Kwan MYW, Chui CSL, et al. Epidemiology of acute myocarditis/pericarditis in Hong Kong adolescents following comirnaty vaccination. Clin Infect Dis 2021; 2021: ciab989.
[http://dx.doi.org/10.1093/cid/ciab989] [PMID: 34849657]
[31]
Crook H, Raza S, Nowell J, Young M, Edison P. Long covid-mechanisms, risk factors, and management. BMJ 2021; 374(1648)
[http://dx.doi.org/10.1136/bmj.n1648] [PMID: 34312178]
[32]
Nabavi N. Long covid: How to define it and how to manage it. BMJ 2020; 370: m3489.
[http://dx.doi.org/10.1136/bmj.m3489] [PMID: 32895219]
[33]
Greenhalgh T, Knight M, A’Court C, Buxton M, Husain L. Management of post-acute covid-19 in primary care. BMJ 2020; 370: m3026.
[http://dx.doi.org/10.1136/bmj.m3026] [PMID: 32784198]
[34]
Proal AD, VanElzakker MB. Long COVID or Post-acute Sequelae of COVID-19 (PASC): An overview of biological factors that may contribute to persistent symptoms. Front Microbiol 2021; 12: 698169.
[http://dx.doi.org/10.3389/fmicb.2021.698169] [PMID: 34248921]
[35]
Centers for Disease Control and Prevention (CDC). Long COVID or Post-COVID Conditions 2022. Available from: https://www.cdc.gov/coronavirus/2019-ncov/long-term-effects/index.html(Accessed on: 2022 Jul 9).
[36]
NICE. COVID-19 rapid guideline: Managing the long-term effects of COVID-10. 2022. Available from: https://www.nice.org.uk/guidance/ng188/resources/covid19-rapid-guideline-managing-the-longterm-effects-of-covid19-pdf-51035515742 (Accessed on: 2022 Jul 9).
[37]
Soriano JB, Murthy S, Marshall JC, Relan P, Diaz JV. A clinical case definition of post-COVID-19 condition by a Delphi consensus. Lancet Infect Dis 2022; 22(4): e102-7.
[http://dx.doi.org/10.1016/S1473-3099(21)00703-9] [PMID: 34951953]
[38]
Zimmermann P, Pittet LF, Curtis N. Long COVID in children and adolescents. BMJ 2022; 376: o143.
[http://dx.doi.org/10.1136/bmj.o143] [PMID: 35058281]
[39]
Leung KKY, Chu SPW, Hon KL, Leung TF. Indirect consequences of covid-19 on children’s health. Hong Kong Med J 2021; 7: 160.
[40]
Petra Z, Laure P, Nigel C. The challenge of studying long COVID: An updated review. Pediatr Infect Dis J 2022; 41(5): 424-6.
[41]
Caspersen IH, Magnus P, Trogstad L. Excess risk and clusters of symptoms after COVID-19 in a large Norwegian cohort. Eur J Epidemiol 2022; 37(5): 539-48.
[http://dx.doi.org/10.1007/s10654-022-00847-8] [PMID: 35211871]
[42]
Fainardi V, Meoli A, Chiopris G, et al. Long COVID in children and adolescents. Life (Basel) 2022; 12(2): 285.
[http://dx.doi.org/10.3390/life12020285] [PMID: 35207572]
[43]
Liang Y, Leung TW, Lian JT, Kee CS. Significant increase in astigmatism in children after study at home during the COVID-19 lockdown. Clin Exp Optom 2022; 2022: 2024071.
[http://dx.doi.org/10.1080/08164622.2021.2024071] [PMID: 35021950]
[44]
Armitage R, Nellums LB. Considering inequalities in the school closure response to COVID-19. Lancet Glob Health 2020; 8(5): e644.
[http://dx.doi.org/10.1016/S2214-109X(20)30116-9] [PMID: 32222161]
[45]
Foster CE, Horwitz A, Thomas A, et al. Connectedness to family, school, peers, and community in socially vulnerable adolescents. Child Youth Serv Rev 2017; 81: 321-31.
[http://dx.doi.org/10.1016/j.childyouth.2017.08.011] [PMID: 30202142]
[46]
Aristovnik A. Keržič D, Ravšelj D, Tomaževič N, Umek L. Impacts of the Covid-19 pandemic on life of higher education students: global survey dataset from the first wave. Data Brief 2021; 39: 107659.
[http://dx.doi.org/10.1016/j.dib.2021.107659] [PMID: 34869802]
[47]
Keržič D, Alex JK, Alvarado PBR, et al.. Academic student satisfaction and perceived performance in the e-learning environment during the COVID-19 pandemic: Evidence across ten countries. PLoS One 2021; 16(10): e0258807.
[http://dx.doi.org/10.1371/journal.pone.0258807] [PMID: 34669757]
[48]
Raza SH, Haq W, Sajjad M. COVID-19: A psychosocial perspective. Front Psychol 2020; 11: 554624.
[http://dx.doi.org/10.3389/fpsyg.2020.554624] [PMID: 33335494]
[49]
de Figueiredo CS, Sandre PC, Portugal LCL, et al. COVID-19 pandemic impact on children and adolescents’ mental health: Biological, environmental, and social factors. Prog Neuropsychopharmacol Biol Psychiatry 2021; 106: 110171.
[http://dx.doi.org/10.1016/j.pnpbp.2020.110171] [PMID: 33186638]
[50]
Luijten MAJ, van Muilekom MM, Teela L, et al. The impact of lockdown during the COVID-19 pandemic on mental and social health of children and adolescents. Qual Life Res 2021; 30(10): 2795-804.
[http://dx.doi.org/10.1007/s11136-021-02861-x] [PMID: 33991278]
[51]
Singh S, Roy D, Sinha K, Parveen S, Sharma G, Joshi G. Impact of COVID-19 and lockdown on mental health of children and adolescents: A narrative review with recommendations. Psychiatry Res 2020; 293: 113429.
[http://dx.doi.org/10.1016/j.psychres.2020.113429] [PMID: 32882598]
[52]
Lee J. Mental health effects of school closures during COVID-19. Lancet Child Adolesc Health 2020; 4(6): 421.
[53]
Ghosh R, Dubey MJ, Chatterjee S, Dubey S. Impact of COVID -19 on children: Special focus on the psychosocial aspect. Minerva Pediatr 2020; 72(3): 226-35.
[http://dx.doi.org/10.23736/S0026-4946.20.05887-9] [PMID: 32613821]
[54]
Li W, Wang Z, Wang G, et al. Socioeconomic inequality in child mental health during the COVID-19 pandemic: First evidence from China. J Affect Disord 2021; 287: 8-14.
[http://dx.doi.org/10.1016/j.jad.2021.03.009] [PMID: 33761325]
[55]
Zhu S, Zhuang Y, Ip P. Impacts on children and adolescents’ lifestyle, social support and their association with negative impacts of the COVID-19 pandemic. Int J Environ Res Public Health 2021; 18(9): 4780.
[http://dx.doi.org/10.3390/ijerph18094780] [PMID: 33947146]
[56]
Hong Kong College of Paediatricians and Hong Kong Society for Paediatric Immunology. Allergy and Infectious Diseases. Prevention of novel coronavirus infection, recommendations for parents. 2020. Available from: http://www.paediatrician.org.hk/index.php?option=com_docman&task=doc_view&gid=1773&Itemid=66 (Accessed on: 2020 Apr 24).
[57]
Wu JT, Mei S, Luo S, et al. A global assessment of the impact of school closure in reducing COVID-19 spread. Philos Trans- Royal Soc, Math Phys Eng Sci 2022; 380(2214): 20210124.
[http://dx.doi.org/10.1098/rsta.2021.0124] [PMID: 34802277]
[58]
Walsh S, Chowdhury A, Braithwaite V, et al. Do school closures and school reopenings affect community transmission of COVID-19? A systematic review of observational studies. BMJ Open 2021; 11(8): e053371.
[http://dx.doi.org/10.1136/bmjopen-2021-053371] [PMID: 34404718]
[59]
Christakis DA, Van Cleve W, Zimmerman FJ. Estimation of US Children’s educational attainment and years of life lost associated with primary school closures during the coronavirus disease 2019 pandemic. JAMA Netw Open 2020; 3(11): e2028786.
[http://dx.doi.org/10.1001/jamanetworkopen.2020.28786] [PMID: 33180132]
[60]
Panda PK, Gupta J, Chowdhury SR, et al. Psychological and behavioral impact of lockdown and quarantine measures for COVID-19 pandemic on children, adolescents and caregivers: A systematic review and meta-analysis. J Trop Pediatr 2021; 67(1): fmaa122.
[http://dx.doi.org/10.1093/tropej/fmaa122] [PMID: 33367907]
[61]
UK Government. COVID-19 Response: Living with COVID-19. 2022. Available from: https://www.gov.uk/government/publications/covid-19-response-living-with-covid-19/covid-19-response-living-with-covid-19 (Accessed on: 2022 Jul 9).
[62]
Leung KK, Hon KL. Lessons from the mink crisis in Europe to chicken culling in Japan: Culling is cruelty and vaccination is a more viable option for animals. Curr Pediatr Rev 2022; 2022: 18.
[PMID: 35297351]
[63]
National Institute of Health. Post-acute Sequelae of SARS-CoV-2 Infection (PASC). 2022. Available from:recovercovid.org/docs/pasc_initiative_fact_sheet.pdf (Accessed on: 2022 Jul 9).

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