Title:Animal Models and Methods of Myocardial Infarction Induction and the
Role of Tissue Engineering in the Regeneration of Damaged Myocardium
Volume: 18
Issue: 5
Author(s): Massoumeh Jabbari Fakhr, Mohammad Reza Mokhber Dezfouli and Sirous Sadeghian Chaleshtori*
Affiliation:
- Institute of
Biomedical Research, University of Tehran, Tehran, Iran
- Department of Internal Medicine, Faculty of Veterinary
Medicine, University of Tehran, Tehran, Iran
Keywords:
Animal model, myocardial infarction, tissue engineering, scaffold, stem cells, Cardiovascular disorders.
Abstract: The introduction of an experimental animal model for myocardial infarction (MI) has particular
importance. Research done on large animals provides valuable information for the researchers because
of the similar characteristics of their hearts compared to humans, but the cost of purchasing and maintaining
them is high. In comparison, using small animals has advantages, such as they are easy to work with
and have low purchase and maintenance costs. However, in some of these animals, due to less similarity
of the heart to humans, they cannot simulate the natural pathogenesis of human MI. Moreover, there are
different methods for the induction of MI in animals; each has its own advantages and disadvantages.
However, a method must be chosen to simulate the natural pathogenesis of MI with minimal complication.
Currently, attempts are being made for myocardial regeneration after MI using the direct transplantation
of stem cells or an engineered scaffold. The scaffold creates a 3D ambiance for the cultured cells.
The task of tissue engineering is to optimize the scaffold with appropriate systems for the separation,
proliferation, and differentiation of the desired cells until they are capable of promoting the threedimensional
and appropriate growth of the tissue. The purpose of tissue engineering in cardiac is the use
of scaffolds and cells in the damaged area, followed by the improvement of the heart function through
automatic pulsation, communication with the host vessels, and electrical coupling with the myocardium,
eventually creating a force to increase the heart function.
