Title:Cobalt Ferrite Nanoparticle’s Safety in Biomedical and Agricultural
Applications: A Review of Recent Progress
Volume: 30
Issue: 15
关键词:
钴铁氧体纳米颗粒，治疗诊断剂，生物系统，生物兼容性，毒理学结果，细胞毒性。
摘要: Cobalt ferrite nanoparticles (CFN) have drawn attention as a theranostic agent.
Unique physicochemical features of CFN and magnetic properties make CFN an outstanding
candidate for biomedical, agricultural, and environmental applications. The extensive
use of CFN may result in intentional inoculation of humans for disease diagnosis and
therapeutic purposes or unintentional penetration of CFN via inhalation, ingestion, adsorption,
or other means. Therefore, understanding the potential cytotoxicity of CFN may pave
the way for their future biomedical and agricultural applications. This review scrutinized
CFN biocompatibility, possible effects, and cytotoxic mechanisms in different biological
systems. Literature indicates CFN toxicity is linked with their size, synthesizing methods,
coating materials, exposure time, route of administration, and test concentrations. Some in
vitro cytotoxicity tests showed misleading results of CFN potency; this might be due to
the interaction of CFN with cytotoxicity assay regents. To date, published research indicates
that the biocompatibility of CFN outweighed its cytotoxic effects in plant or animal
models, but the opposite outcomes were observed in aquatic Zebrafish.
