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Current Medicinal Chemistry

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ISSN (Online): 1875-533X

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Review Article

Nanoparticle-based CRISPR/Cas Delivery: An Emerging Tactic for Cancer Therapy

Author(s): Fahima Dilnawaz* and Sarbari Acharya*

Volume 30, Issue 31, 2023

Published on: 21 December, 2022

Page: [3562 - 3581] Pages: 20

DOI: 10.2174/0929867329666221006112615

Price: $65

Abstract

Genome editing arose as a new promising approach for treating numerous intricate ailm ents including cancer. Over the past couple of decades, delivery technologies that have serendipitously been developed using viral vectors are successful to some extent in protein and nucleic acid delivery but their effectiveness still lags due to their efficiency, tissue targeting capabilities, and toxicity which must be further improved. With the infiltration of nanotechnology into every sphere of life, nano-vehicles can be implemented as an ideal modality that can overcome challenges, also can be introspective as new genome editing tools for cancer therapy owing to the safety and efficiency in clinical settings. Such projected substitution can help in developing highly efficacious therapy regimes which are successful in clinical settings. This emerging approach of incorporation of genome editors (CRISPR/Cas) in different nano vehicles and their utility in targeting various aspects of cancer therapy like treatment, diagnostics, modelling has been comprehensively done in this review.

Keywords: CRISPR, Cas9, nanotechnology, nanoparticles, cancer, gene editing.

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