Title:Achievements and Bottlenecks of PEGylation in Nano-delivery
Systems
Volume: 30
Issue: 12
关键词:
聚乙二醇化,药物递送,生物偶联,纳米医学,抗PEG抗体,PEG免疫原性
摘要: Poly(ethylene glycol) (PEG) has been widely applied in the biomedical field
as a gold standard. The conjugation of PEG to proteins, peptides, oligonucleotides (DNA,
small interfering RNA (siRNA), microRNA (miRNA)) and nanoparticles, also
known as PEGylation, is a common method to improve the efficiency of drug delivery
and pharmacokinetics in vivo. The effect of PEGylation on the in vivo fate of various formulations
has been and continues to be extensively studied based on the successful PEGylation
of proteins to improve in vivo circulation time and reduce immunogenicity. The
PEG shell protects the particles from aggregation, immune recognition, and phagocytosis,
thereby prolonging the in vivo circulation time. This article mainly describes the development
background, advantages and applications of PEGylation in the field of drug
delivery, its defects or development bottlenecks, and possible alternatives.