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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Review Article

嵌合抗原受体(CAR) t细胞治疗:癌症免疫治疗的一种新的基因工程方法

卷 23, 期 3, 2023

发表于: 13 October, 2022

页: [199 - 210] 页: 12

弟呕挨: 10.2174/1568009622666220928141727

价格: $65

摘要

嵌合抗原受体(CAR-T)细胞治疗实体瘤面临重大挑战。由于缺乏内皮白细胞粘附分子，CAR-T细胞无法在肿瘤中通过血管屏障。CAR-T细胞的侵袭、活性和持久性可能受到实体瘤环境中存在的额外免疫抑制机制的阻碍。使用CAR-T细胞从血液内攻击癌症血管内皮代谢靶点可能会简化对抗癌症的过程。这些是指导我们检查CAR-T细胞对肿瘤细胞治疗的原则，特别关注肿瘤静脉给药。CAR-T细胞也可以被设计成可以轻易、安全、成功地转移。

关键词: 实体瘤，血管生成，靶向治疗，CAR-T细胞，血液扩散，肿瘤。

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