Title: Potential Lithium and Fluoride Interactions in Studies of Glycogen Synthase Kinase-3
Volume: 4
Issue: 3
Author(s): Anna Strunecka and Jiri Patocka
Affiliation:
Keywords:
Glycogen synthase kinase-3 (GSK-3), lithium, fluoride, aluminofluoride complexes, protein phosphatase -1
Abstract: The discoveries of the pluripotent role of glycogen synthase kinase-3 (GSK-3) are pointing to GSK-3 as a potential target for therapy of neurodegenerative disorders and type 2 diabetes. GSK-3 is a constitutively active protein kinase that is inhibited in response to various extracellular signals. Lithium has been found to be an important inhibitor of GSK-3 activity and its use as a laboratory tool has contributed to the understanding of the role of GSK-3. Fluoride has been often used in study designs on GSK-3 as the inhibitor of protein phosphatases. Potential interactions of fluoride with the observed lithium effects are discussed.
