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Mini-Review Article

癫痫病的靶点和药物:A Mini-Review

卷 24, 期 3, 2023

发表于: 27 October, 2022

页: [212 - 224] 页: 13

弟呕挨: 10.2174/1389450123666220927103715

价格: $65

Open Access Journals Promotions 2
摘要

背景：癫痫是一种神经系统疾病，受大脑中抑制和兴奋信号失衡的影响。引言：在这种疾病中，靶点在病理生理学中是活跃的，因此可以作为药物治疗的焦点。 方法：多项研究证明了药物对以下靶点的抗癫痫作用：N-甲基-D-天冬氨酸（NMDA）、α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）受体、电压门控钙通道（Cav）、γ-氨基丁酸转运体1型（GAT1）、电压门控钠通道（Nav）、，Q亚家族的电压门控钾通道（KCNQ）和A型γ-氨基丁酸（GABAA）受体。 结果：这些研究突出了分子对接的重要性。 结论：定量构效关系（QSAR）和计算机辅助药物设计（CADD）在预测这些靶点可能的药理活性中的作用。

关键词: 分子对接、AMPA、NMDA、GAT1、KCNQ、Cav、Nav和GABAA。

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