Title:Design, Synthesis, and Antiproliferative Activity of Novel Flavone Derivatives
Volume: 20
Issue: 10
Author(s): Lata C. Potey*, Prafulla M. Sabale and Vidya P. Sabale
Affiliation:
- Shree Sainath College of Pharmacy, Nagpur, India
Keywords:
Flavones, fadrozole, breast cancer, MCF-7, cytotoxicity, comet assay, MTT assay.
Abstract:
Background: Cancer is a complex disease in which some of the cells grow uncontrollably and
spread to other parts of the body.
Objective: The present study focuses on molecular docking and synthesis of novel flavone derivatives
substituted with heterocyclic rings.
Methods: The anticancer activity of novel flavones against human aromatase enzyme using human breast
cancer cell line MCF-7 through MTT assay was demonstrated. The synthesized compounds for the determination
of single or double-strand DNA damage through the single-cell electrophoresis/comet assay
were evaluated.
Results: In this study, we found that the derivative 3M with morpholine ring showed the highest anticancer
potency against the MCF-7 cell line compared to that of other flavone derivatives. Compound 3T
showed less cytotoxicity against the MCF-7 cell line.
Conclusion: Based on the findings, flavone scaffolds can be selected as a skeleton for the development of
heterocyclic amine-containing flavones with the potential to develop as anticancer drugs.
