Title:The Correlation Between Modified Total Cerebral Small Vessel Disease
Score and Gait and Balance Disorder in Middle-aged to Older Adults
Volume: 19
Issue: 3
Author(s): Yutong Hou, Shuna Yang, Yue Li, Wei Qin, Lei Yang and Wenli Hu*
Affiliation:
- Department of Neurology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
Keywords:
Cerebral small vessel disease, modified CSVD score, gait, balance, motor disturbance, ischemic stroke.
Abstract:
Background and Aims: The aim of this study is to investigate the relationships between
the original and modified total cerebral Small Vessel Disease (CSVD) score and gait and balance
impairment using quantitative and semi-quantitative tests.
Methods: In our study, patients aged 45 to 85 consecutively recruited. CSVD manifestations were
identified with brain Magnetic Resonance Imaging (MRI), and the original and modified CSVD
scores were calculated based on the results. Gait and balance function were assessed using both gait
parameters and clinical rating scales. The correlation between the original and modified total scores
of the CSVD and gait and balance dysfunction was demonstrated.
Results: 224 patients were enrolled in the study. Gait and balance disorders were associated with
both the original and modified CSVD scores. A significant association remained after adjusting for
gender, height, age, hypertension, and other relevant risk factors. The binary logistic regression and
chi-squared trend tests revealed that impairment of movement function significantly correlated with
the modified CSVD score and that the dysfunction was significantly higher for patients with modified
CSVD scores of 5-6 than those with scores of 1-2. In Receiver Operating Characteristic (ROC)
analysis, modified CSVD scores were more accurate in predicting gait impairment than original
CSVD scores.
Conclusion: We found both original and modified total CSVD scores to be related to gait and balance
disorder, and the modified CSVD score was more accurate in identifying movement impairment
and should be used as an effective tool in investigating CSVD and motor dysfunction.
