Title:In vivo PET Imaging of EGFR Expression: An Overview of Radiolabeled
EGFR TKIs
Volume: 22
Issue: 28
Author(s): Jing Zhu, Yalun Li, Xiaoai Wu, Yunchun Li, Li Wang*Hong Fan*
Affiliation:
- Department of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China
- Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, 610041,
China
Keywords:
Epidermal growth factor receptor, Non-small-cell lung cancer, Tyrosine kinase inhibitors, PET, Noninvasive, In vivo.
Abstract: With the development of epidermal growth factor receptor (EGFR)-based tyrosine kinase
inhibitors (TKIs) and their applications in the clinic, non-small-cell lung cancer (NSCLC) treatment
has entered a new era, and a great number of patients have benefited. However, there still exist other
subgroups of patients who may not benefit from EGFR TKIs, although EGFR mutation is the
main driving mutation that leads to NSCLC. To identify potential NSCLC responders for TKI therapy
and to detect EGFR status in vivo, noninvasive technology, such as TKI PET imaging, has been
developed in recent years, and a great number of tyrosine kinase-targeted PET tracers have been reported.
The visualization and quantification of EGFR expression in vivo by PET would provide the
most important information for personalizing NSCLC therapy and prediction of response in clinical.
This article reviews the progress of small molecular tyrosine kinase-targeted PET tracers and their
applications in preclinical experiments and clinical studies. The current limitations and future development
of these tracers are also briefly discussed.
