Title:Amalgamation of Nanoparticles within Drug Carriers: A Synergistic
Approach or a Futile Attempt?
Volume: 10
Issue: 5
Author(s): Nikhil Mehta and Rohan Pai*
Affiliation:
- Department of Pharmaceutics, Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management,
SVKM's NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai - 400056, India
Keywords:
Amalgamated, nanoparticles, multi-component, drug carriers, fusion, nanotechnology.
Abstract: In recent years, nanotechnology has gained much attention from scientists for the
obtainment of significant advances in therapeutic potential. Nano-delivery systems have emerged
as an effective way to improve the therapeutic properties of drugs, including solubility, stability,
prolongation of half-life, as well as promoting the accumulation of drug at the target site. The
nanoparticles have also been incorporated into various conventional drug delivery systems. This
review study aims to introduce the amalgamation of nanoparticles into drug carriers. To overcome
the limitations of single nanoparticles, such as toxicity, high instability, rapid drug release as well
as limited drug loading capacity, a multi-component system is developed. Liposomes,
microparticles, nanofibers, dendrimers, etc., are promising drug carriers, having some limitations
that can be minimized, and the compilation of nanoparticles synergizes the properties. The
amalgamated nanocarriers are used for the diagnostic purpose as well as treatment of various
chronic diseases. It also increases the solubility of hydrophobic drugs. However, each system has
its advantages and disadvantages based on its physicochemical properties, efficacy, and other
parameters. This review details the past and present state of development for the fusion of
nanoparticles within drug carriers and future research works are needed for the same.
