Title:Role of Solid Lipid Nanoparticles for the Delivery of Lipophilic Drugs and
Herbal Medicines in the Treatment of Pulmonary Hypertension
Volume: 10
Issue: 5
Author(s): Tanuja Bhatia, Ghanshyam Das Gupta, Balak Das Kurmi and Dilpreet Singh*
Affiliation:
- Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab 142001, India
Keywords:
Pulmonary arterial hypertension, solid lipid nanoparticle, drugs, solubility, bioavailability, first-line carrier.
Abstract: Pulmonary arterial hypertension (PAH) is an uncommon condition marked by elevated
pulmonary artery pressure that leads to right ventricular failure. The majority of drugs are now being
approved by FDA for PAH, however, several biopharmaceutical hindrances lead to failure of the
therapy. Various novel drug delivery systems are available in the literature from which lipid-based
nanoparticles i.e. solid lipid nanoparticle is widely investigated for improving the solubility and
bioavailability of drugs. In this paper, the prototype phytoconstituents used in pulmonary arterial
hypertension have limited solubility and bioavailability. We highlighted the novel concepts of SLN
for lipophilic phytoconstituents with their potential applications. This paper also reviews the present
state of the art regarding production techniques for SLN like High-Pressure Homogenization, Microemulsion
Technique, and Phase Inversion Temperature Method, etc. Furthermore, toxicity aspects
and in vivo fate of SLN are also highlighted in this review. In a nutshell, safer delivery of phytoconstituents
by SLN added a novel feather to the cap of successful drug delivery technologies.
