Title:Functional Excipients and Novel Drug Delivery Scenario in
Self-nanoemulsifying Drug Delivery System: A Critical Note
Volume: 10
Issue: 5
Author(s): Russel Tonjan and Dilpreet Singh*
Affiliation:
- Department of Pharmaceutics, ISF College of Pharmacy, GT Road (NH-95), Ghal Kalan, Moga, Punjab 142001,
India
Keywords:
SNEDDS, lipid, excipient, absorption, poor solubility, lipophilic, physicochemical.
Abstract: Lipid-based formulations have emerged as prospective dosage forms for extracting the therapeutic
effects of existing lipophilic compounds and novel chemical entities more efficiently. Compared
to other excipients, lipids have the added benefit of enhancing the bioavailability of lipophilic
and highly metabolizable drugs due to their unique physicochemical features and similarities to in vivo
components. Furthermore, lipids can minimize the needed dose and even the toxicity of drugs with
poor aqueous solubility when employed as the primary excipient. Hence, the aim of the present review
is to highlight the functional behavior of lipid excipients used in SNEDD formulation along with the
stability aspects of the formulation in vivo. Moreover, this review also covered the importance of
SNEDDS in drug delivery, the therapeutic and manufacturing benefits of lipids as excipients, and the
technological advances made so far to convert liquid to solid SNEDDS like melt granulation, adsorption
on a solid support, spray cooling, melt extrusion/ spheronization has also highlighted. The mechanistic
understanding of SNEDD absorption in vivo is highly complex, which was discussed very critically
in this review. An emphasis on their application and success on an industrial scale was presented,
as supported by case studies and patent surveys.
