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Mini-Reviews in Medicinal Chemistry

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ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

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Systematic Review Article

Association between Chlamydia trachomatis Infection and Male Infertility: A Systematic Review and Meta-Analysis

Author(s): Masoud Keikha, Seyed-Abolfazl Hosseininasab-Nodoushan and Amirhossein Sahebkar*

Volume 23, Issue 6, 2023

Published on: 03 October, 2022

Page: [746 - 755] Pages: 10

DOI: 10.2174/1389557522666220827160659

Abstract

Background: Chlamydia trachomatis infection is one of the most common sexually transmitted diseases. There is widespread evidence in recent years that indicate C. trachomatis infection plays a role in sperm dysfunction and poor sperm quality. However, some controversial documents have argued the role of infection with this bacterium in male infertility.

Methods: A full comprehensive electronic search was performed using the online databases Web of Science, PubMed, Scopus, Embase, and Google Scholar, without considering the time limits.

Results: In the present study, 56 articles were finally found to be eligible. The prevalence of C. trachomatis infection in the infertile males was estimated at 20.6% (19.8-21.5 with 95% CIs; p- Value: 0.01; I2: 97.77; Q-Value: 237.8; p-Value: 0.01; Begg's p-Value: 0.09; Egger's p-Value: 0.01) in overall. We have also shown that infection with C. trachomatis can significantly increase the risk of infertility in men (OR: 2.28; 1.90-2.72 with 95% CIs; p-Value: 0.001; I2: 81.61; QValue: 59.81; p-Value: 0.01; Begg's p-Value: 0.73; Egger's p-Value: 0.61).

Conclusion: We showed a high prevalence of C. trachomatis in the sperm and semen samples of infertile men, and C. trachomatis infection is associated with a significantly higher risk of infertility in men.

Keywords: Chlamydia trachomatis, infertility, infection, meta-analysis, sperm, prevalence.

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