Title:In Silico Identification of Human miR-26a-1 from Hypertension Genome
Sequence
Volume: 18
Issue: 1
Author(s): K. Auxzilia Preethi, Sushmaa Chandralekha Selvakumar and Durairaj Sekar*
Affiliation:
- Centre for Cellular and Molecular Research, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and
Technical Sciences (SIMATS), Saveetha University, Chennai-77, India
Keywords:
Hypertension, miRNAs, biomarkers, therapeutic target, hsa-miR-26a-1, heart failure.
Abstract:
Background: Hypertension is a global public health issue that is becoming more prevalent.
It is a non-communicable disease and a great public health problem affecting almost half of
the world’s adult population. Being multifactorial, hypertension is a key risk factor for stroke, coronary
artery disease, heart failure, and chronic renal failure. However, the cellular and molecular
mechanisms that regulate it remain mostly unknown. According to numerous studies, microRNAs
(miRNAs) have been implicated in a range of cellular processes in the development of illnesses.
The current study aims to identify miRNAs in hypertension from genome sequences found in public
genomic databases.
Materials and Methods: In this study, we have used bioinformatic approaches to identify miR-26a-
1 for hypertension using the NCBI database, miRBase and target scan. Finally, the RNA fold was
used to create the secondary structure of miR-26a-1.
Results and Discussion: Careful evaluation of secondary structure result showed that hsa-miR-
26a-1 has a minimum free energy of - 37.30 kcal. The correlation between miR-26a-1 and hypertension
genome sequence was identified.
Conclusion: These computational approaches have concluded that miR-26a-1 can be used as a diagnosis,
prognosis and effective therapeutic target for treating hypertension. Thus, further research
could enlighten the role of miR-26a-1 in hypertension.
