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Review Article

杂交组蛋白去乙酰化酶抑制剂：癌症治疗的有效策略

卷 30, 期 20, 2023

发表于: 21 October, 2022

页: [2267 - 2311] 页: 45

弟呕挨: 10.2174/0929867329666220826163626

价格: $65

摘要

抑制组蛋白脱乙酰酶（HDACs）已被证明是癌症治疗的有效策略。迄今为止，五种组蛋白去乙酰化酶抑制剂（HDACis）已被批准用于癌症治疗，许多其他抑制剂正在进行临床试验。与单效药物相比，可以同时有效地抑制两个或多个靶点的药物在预防治疗耐药性和增强协同作用方面可能提供更大的治疗益处。双功能剂的一个主要例子是混合HDACi。本文将总结代表性的混合HDAC类型，以阐明用于癌症治疗的新型混合HDACis的设计。

关键词: 组蛋白脱乙酰酶，杂交，多靶点抑制剂，抗肿瘤，癌症治疗，双功能剂。

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