Title:Nanogel-based Transdermal Drug Delivery System: A Therapeutic Strategy
with Under Discussed Potential
Volume: 23
Issue: 1
Author(s): Lubna Tariq, Azher Arafah, Shafat Ali, Saba Beigh, Mashooq Ahmad Dar, Tanvir ul Hassan Dar, Aqib Iqbal Dar, Rana M. Alsaffar, Mubashir Hussain Masoodi and Muneeb U. Rehman*
Affiliation:
- Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
Keywords:
Nanotechnology, Nanogels, Hydrogels, Transdermal drug delivery system, Gel matrix, Therapeutics.
Abstract: The application of nanoparticles in medication delivery has revolutionized the field of
therapeutic biology. To improve medical efficacy, currently, drug nanocarriers are employed to control
the release and stability, expand its circulation time, or protect it from cell clearance or premature
breakdown. A crosslinked polymeric framework is used to crosslink the hydrogel nanoparticle
dispersions for safer and stable delivery on target sites. Nanogels have developed in the last two
decades as potential biomaterials with a wide variety of applications. Later attributes of nanogels
are mainly due to large surface areas, retention of molecules, size flexibility, and water-based formulations
that have made them popular as drug delivery vehicles, as seen by several in vivo uses.
The gel matrix containing the nanoparticle drug demonstrated a considerable increase in drug penetration
in transdermal drug and topical delivery methods. This review aims to understand why and
how nanogels are considered so innovative as a drug delivery method. It also examines their preparation
methods and applications in the pharmaceutical and biomedical fields and discusses the benefits
of nanogels, including swelling capacity and stimulus stimuli sensitivity. Nanogels, on the other
hand, have recently been investigated for applications outside the field of biomedicine. Since there
are many possible uses for nanogels, we have comprehensively reviewed the current state of the art
for all feasible nanogel applications and manufacturing methods.
