Title:Diabetic Neuropathy: A Repercussion of Vitamin D Deficiency
Volume: 19
Issue: 6
Author(s): Prerna Sharma, Nidhi Rani*, Aishwarya Gangwar, Randhir Singh, Rajwinder Kaur and Kumud Upadhyaya
Affiliation:
- Chitkara College of Pharmacy, Chitkara University, Punjab, India
Keywords:
Diabetes, diabetic neuropathy, vitamin D deficiency, HbA1c, hyperglycemia, cholecalciferol.
Abstract: Diabetes mellitus is a crucial health issue worldwide. The worldwide ubiquity is 8.8%
among adults, which is predicted to rise to 10.4% by 2040. Diabetic neuropathy is a long-term
complication associated with the diabetes mellitus condition, which primarily targets Schwann
cells, peripheral axons and cell bodies (perikarya) in DRG (dorsal root ganglia). It can be accompanied
by different factors such as metabolic factors such as insulin resistance, hypertension, obesity,
low HDL level, and hypertriglyceridemia. The etiology of DPN is multifactorial. It is caused
by hyperglycemia, micro-angiopathy, HbA1c, duration of diabetes, smoking status, high-density
lipoprotein cholesterol and hypertension. Also, increased glucose conditions decrease vitamin D
levels. Vitamin D, which is involved in neurotrophins such as NGF (nerve growth factor) and NCH
(neuronal calcium homeostasis), plays a neuroprotective role in peripheral nerves. Depletionleads
to vitamin D deficiency which further develops peripheral neuropathy in diabetic patients. Accumulation
of AGEs (advanced glycation end product) plays a significant role in the pathogenesis of
sensory neuronal damage. It contributes to microangiopathy and endoneurial vascular dysfunction
in peripheral nerves. With vitamin D supplementation, the neuropathy pain scores were improved.
