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Review Article

2,5-二酮哌嗪:来源、合成、生物活性、结构和质谱破碎的综述

卷 30, 期 9, 2023

发表于: 21 September, 2022

页: [1060 - 1085] 页: 26

弟呕挨: 10.2174/0929867329666220801143650

价格: $65

摘要

背景:2,5-二酮哌嗪(DKPs)，又称环二肽，是自然界中由两个氨基酸缩合形成的最简单的肽衍生物。它们是一类重要的生物活性物质，具有多种结构。 目的:本文综述了简单DKPs的天然来源、合成工艺、生物学特性及MS破碎规律，以期为进一步探索该类化合物的科学和治疗潜力提供参考。 方法:从多个电子科学数据库(如:Web of Science、China Knowledge Resource Integrated、ScienceDirect、PubMed、万方数据和谷歌Scholar)、博士和硕士学位论文中收集和整理相关信息。这项工作回顾了从20世纪初到2021年发表的107篇文章。 结果:从真菌、细菌、植物和动物等广泛的自然资源中获得了DKPs，并通过化学和生物方法合成了DKPs。DKPs具有多种药理活性，包括抗癌、抗菌、抗血栓、神经元保护、镇痛等活性。质谱分析是dkp结构分析最常用的方法。根据质谱碎片模式，质谱可以快速筛选和鉴定DKPs。 结论:DKPs是一类相对未知的化合物，已被证实具有多种生物活性，尤其是抗肿瘤和抗菌活性。然而，现有的关于DKPs的研究仍处于早期阶段，其在药物开发中的应用还有待进一步研究。

关键词: 2,5-二酮哌嗪类，环二肽，生物活性，质谱，碎片，质谱碎片模式。

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