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Review Article

脂质吞噬：糖尿病肾病的潜在治疗靶点

卷 30, 期 16, 2023

发表于: 04 October, 2022

页: [1875 - 1886] 页: 12

弟呕挨: 10.2174/0929867329666220727113129

价格: $65

摘要

糖尿病肾病（DN）是糖尿病的严重并发症，也是终晚肾病（ESRD）的主要原因之一。导致DN进展的因素很多。脂质代谢紊乱是DN的常见临床表现，异位肾脂质沉积最近被认为是促进DN发展的关键因素。脂质吞噬是一种新发现的选择性自噬，可以清除细胞中过量的脂质以维持脂质稳态。最近，嗜脂性异常也与DN的进展有关。在这里，我们讨论了脂滴的形成，描述了亲脂性及其关键调节信号，总结了目前DN中亲脂性的研究进展，最后提出亲脂性可能是治疗DN的潜在靶点。

关键词: 糖尿病肾病（DN），嗜脂性，脂滴，脂质稳态，自噬，肾脏。

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