Title:Enzymatic Strategies for the Preparation of Pharmaceutically Important
Amino Acids through Hydrolysis of Amino Carboxylic Esters
and Lactams
Volume: 29
Issue: 41
Author(s): Enikő Forró*Ferenc Fülöp
Affiliation:
- Institute of Pharmaceutical Chemistry, University of Szeged, H-6720 Szeged, Eötvös u. 6, Hungary
- Stereochemistry Research Group of the Hungarian Academy of Sciences
University of Szeged, H-6720 Szeged, Eötvös u. 6, Hungary
Keywords:
Enantiomeric α-amino carboxylic acid, enantiomeric β-amino carboxylic acid, enantiomeric γ-amino carboxylic acid, hydrolysis, lipase, KR, DKR, SKR.
Abstract: The most relevant lipase-catalyzed strategies for the synthesis of pharmaceutically
important cyclic and acyclic α-, β- and γ-amino carboxylic acid enantiomers through
hydrolysis of the corresponding amino carboxylic esters and lactams, over the last decade
are overviewed. A brief Introduction part deals with the importance and synthesis of enantiomeric
amino acids, and formulates the objectives of the actual work. The strategies are
presented in the Main Text, in chronological order, classified as kinetic, dynamic kinetic
and sequential kinetic resolution. Mechanistic information of the enzymatic transformations
is also available at the end of this overview. The pharmacological importance of
the enantiomeric amino acids is given next to their synthesis, in the Main Text, and it is
also illustrated in the Conclusions and Outlook sections.
