Title:The Potential Therapeutic Impact of Metformin in Glioblastoma
Multiforme
Volume: 30
Issue: 7
关键词:
多形性胶质母细胞瘤，二甲双胍，抗癌，AMPK，增殖，癌症。
摘要: In terms of frequency and aggressiveness, glioblastoma multiforme (GBM) is
undoubtedly the most frequent and fatal primary brain tumor. Despite advances in clinical
management, the response to current treatments is dismal, with a 2-year survival rate
varying between 6 and 12 percent. Metformin, a derivative of biguanide widely used in
treating type 2 diabetes, has been shown to extend the lifespan of patients with various
malignancies. There is limited evidence available on the long-term survival of GBM
patients who have taken metformin. This research examined the literature to assess the
connection between metformin's anticancer properties and GBM development. Clinical
findings, together with the preclinical data from animal models and cell lines, are included
in the present review. This comprehensive review covers not only the association of
hyperactivation of the AMPK pathway with the anticancer activity of metformin but also
other mechanisms underpinning its role in apoptosis, cell proliferation, metastasis, as
well as its chemo-radio-sensitizing behavior against GBM. Current challenges and future
directions for developments and applications of metformin-based therapeutics are also
discussed.
