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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Mini-Review Article

靶向转化生长因子-信号通路在妇科癌症治疗中的作用

卷 23, 期 1, 2023

发表于: 05 September, 2022

页: [15 - 24] 页: 10

弟呕挨: 10.2174/1568009622666220623115614

价格: $65

摘要

转化生长因子-β (TGF-β)信号通路已被报道在包括妇科癌症在内的几种恶性肿瘤的发病机制中被调节失调。这证明了它作为宫颈癌治疗靶点和预后生物标志物的潜在价值。本文概述了TGF-β抑制剂在妇科癌症中作为单一药物或联合治疗的生物学作用和临床影响，重点介绍了I期至II/III期临床试验。异常的TGF-β信号可能导致癌变。抑制TGF-β是妇科癌症治疗的一个有趣的重点领域。几种TGF-β抑制剂是潜在的抗癌药物，正在进行癌症临床试验，包括galunisertib, dalantercept和vigil。有越来越多的数据显示靶向TGF-β通路在不同癌症类型中的潜在治疗影响，尽管还需要进一步的研究来探索这一策略的价值，并找到最适合从治疗中获益的患者。

关键词: TGF-β通路，TGF-β抑制剂，妇科癌症，靶向治疗，抗癌药物，恶性肿瘤。

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