Title:Fasting Plasma Glucose and Glycohemoglobin with Allergic Symptoms
and Specific Sensitization: Results from NHANES 2005-2006
Volume: 26
Issue: 5
Author(s): Gan Lu, Yu-Qin Deng, Yang Xi, Song Li, Shi-Ming Chen, Yong-Gang Kong, Yu Xu, Fen Li and Ze-Zhang Tao*
Affiliation:
- Department of Otolaryngology, Head and Neck Surgery, Renmin Hospital of Wuhan University, 238 Jie-Fang Road,
Wuhan, Hubei 430060, P.R. China
- Institute of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan
University, Wuhan, Hubei 430060, P.R. China
Keywords:
Fasting plasma glucose (FPG), glycohemoglobin (A1c), allergic symptoms, specific sensitization, National Health and Nutrition Examination Survey (NHANES), specific immunoglobulin E (sIgE), diabetes.
Abstract:
Objective: The National Health and Nutrition Examination Survey (NHANES) data has
been used to study the relationship between fasting plasma glucose (FPG) and glycohemoglobin
(A1c) in patients with allergic symptoms and specific sensitization, respectively.
Methods: A total of 1,687 participants and a variety of logistic regression models were selected
based on the 2005-2006 NHANES (n = 10,348) for our study to describe the relationship between
FPG and A1c in subjects with the sensitivity of allergic symptoms, specific sensitization and specific
sensitization of 19 allergens, respectively. On this basis, a variety of logistic regression models
were further established for hierarchical analysis to study the limiting conditions when FPG and
A1c were related to allergic symptoms.
Results: We adjusted the confounding factors and found that the risk of specific sensitization increased
with the increase in FPG and A1c. Stratified analysis showed that the risk of allergic symptoms
increased with the increase in FPG and A1c when born elsewhere other than in the U.S. and
Mexico or underweight or overweight or with hypertension. Furthermore, we found that the risk of
egg sensitization increased with the increase in FPG and A1c, while the risk of rat sensitization decreased
with the increase in FPG.
Conclusion: Under certain conditions, FPG and A1c were risk factors for allergic symptoms. FPG
and A1c were risk factors for specific sensitization, especially egg sensitization. These findings indicate
a possible link between diabetes and allergies.
