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Mini-Reviews in Medicinal Chemistry

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ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

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Review Article

AGAP2-AS1: An Indispensable lncRNA in Tumors

Author(s): Jinlan Chen and Bei Wang*

Volume 23, Issue 3, 2023

Published on: 16 September, 2022

Page: [336 - 342] Pages: 7

DOI: 10.2174/1389557522666220615154227

Abstract

Background: LncRNA has been found to participate in a variety of biological processes and play an important role in the occurrence and development of tumors. Therefore, it is of vital clinical value to study the relationship between lncRNA and tumor. It has been confirmed that lncRNA affects tumor progression through sponge mRNA, regulation of signal pathways and activity of oncogenes. Recent studies have shown that LncRNA AGAP2-AS1 is closely related to tumor, because this review focuses on the molecular mechanism of LncRNA AGAP2-AS1 affecting tumor progression.

Methods: The role of LncRNAAGAP2-AS1 in tumor was summarized by searching the literature related to LncRNAAGAP2-AS1 from PubMed in recent years.

Results: LncRNA AGAP2-AS1 is abnormally expressed as an oncogene in tumors, which participates in biological processes such as tumor proliferation, migration, invasion and autophagy. LncRNA AGAP2-AS1 plays an important role in tumorigenesis and development by binding to mRNA, regulating signal pathway and affecting protein activity, which suggests that AGAP2- AS1 may play a great potential value in the treatment of human cancer.

Conclusion: The abnormal expression of LncRNAAGAP2-AS1 plays an important role in the progression of tumor and has a promising value in the treatment of tumor. Exploring the molecular mechanism of lncRNA AGAP2-AS1 is of indispensable significance for tumor treatment.

Keywords: Long noncoding RNA, AGAP2-AS1, tumorigenesis biomarker, potential therapeutic target, LncRNAAGAP2-AS1, human cancer.

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