Title:Transition Metal Coordination Complexes of Flavonoids: A Class of Better Pharmacological
Active Molecules to Develop New Drugs
Volume: 23
Issue: 4
Author(s): Sushmitha Jayaprakash, Sruthi Ramesh, Aishwarya Karthikeyan, Sivasubramanian Murugappan, Priyadharshini Sidharthan and Stalin Selvaraj*
Affiliation:
- Centre for Nanotechnology & Advanced Biomaterials, SASTRA Deemed University, Thanjavur - 613 401, India
- School of Chemical
& Biotechnology, SASTRA Deemed University, Thanjavur - 613 401, India
Keywords:
Antioxidant, flavonoids, antidiabetic, biological activity, antimicrobial, metal complexes, anticancer, parent flavonoid.
Abstract: Flavonoid metal ion complexes are one of the classes of biologically active molecules with immense pharmacological
potential, including antioxidant, antidiabetic, antimicrobial, and anticancer activity, to name a few. The
effectiveness of this complexion depends on the state and nature of the transition metal ions and on the position to
which the metal ion coordinates with their corresponding parent flavonoid. The metal coordination of flavonoids also
improves the biological activities to a maximum extent compared to the parent compound. This may be attributed to
many factors such as metal ions, coordination sites, structural configuration, and stability of the complexes. On the
other hand, some of the metal ion complexes reduce the biological efficiency of the corresponding parent flavonoids,
which can be due to the shift from antioxidant to pro-oxidant nature as well as the stability of the complexes both in in
vitro and in vivo conditions. However, the literature on the stability of flavonoid metal ion complexes in in vivo conditions
is very scanty. Therefore, this review summarizes and critically addresses all these parameters a favor together in
a single slot that favours for the researchers to put forward to understand the mode and detailed molecular mechanism
of flavonoid metals complexes compared with their corresponding parent flavonoids.
