Title:Natural Flavonoid Quercetin Enhances the Anti-inflammatory
Effects of Aspirin in a Preeclampsia-like Rat Model Induced by
Lipopolysaccharide
Volume: 23
Issue: 5
关键词:
先兆子痫，阿司匹林，槲皮素，脂多糖，巨噬细胞，发病机制。
摘要:
Background: Preeclampsia is a disorder of hypertension and proteinuria
accompanied by abnormal inflammatory responses. Both aspirin and quercetin possess
anti-inflammatory and anti-hypertensive properties. A low dose of aspirin is
recommended for the prevention of preeclampsia in patients with preeclampsia history.
Whether quercetin can enhance the effect of aspirin on preeclampsia remains elusive.
Methods: Female Sprague-Dawley pregnant rats were treated with daily administration
of aspirin, quercetin, or a combination of aspirin and quercetin and subsequently
received lipopolysaccharides (LPS) injection to induce preeclampsia-like symptoms. The
systolic blood pressure and proteinuria from all groups of rats were assessed.
Results: Our results demonstrated that the combination of quercetin and aspirin exerted
significantly stronger effects than aspirin alone on decreasing systolic blood pressure
and proteinuria, reducing pro-inflammatory cytokine production, and inhibiting M1-type
decidual macrophages polarization in an LPS-induced rat model of preeclampsia.
Conclusion: This study suggested that quercetin may serve as an excellent supplement
to aspirin in preventing or treating patients with preeclampsia.
