hiPSC-Neural Stem/Progenitor Cell Transplantation Therapy for Spinal
Cord Injury

Xiaofeng      Du; Asiamah   Ernest   Amponsah; Desheng      Kong; Jingjing      He; Zhenhuan      Ma; Jun      Ma; Huixian      Cui
doi:10.2174/1574888X17666220509222520
Abstract

Spinal cord injury (SCI) is a catastrophic event that incurs substantial personal and social costs. The complex pathophysiology associated with SCI often limits the regeneration of nerve tissue at the injured site and leads to permanent nerve damage. With advances in stem cell biology, the field of regenerative medicine offers the hope of solving this challenging problem. Neural stem/progenitor cells (NSPCs) possess nerve regenerative and neuroprotective effects, and transplanting NSPCs in their optimized form into an injured area holds promising therapeutic potential for SCI. In this review, we summarize the advantages and disadvantages of NSPCs derived from different sources while highlighting the utility of NSPCs derived from induced pluripotent stem cells, an NSPC source with superior advantages, according to data from in vivo animal models and the latest clinical trials.
Keywords: Spinal cord injury, hiPSC, neural stem cell, neural progenitor cell, transplantation, neuroprotective effects.
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Graphical Abstract

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DOI https://dx.doi.org/10.2174/1574888X17666220509222520	Print ISSN 1574-888X
Publisher Name Bentham Science Publisher	Online ISSN 2212-3946
Current Stem Cell Research & Therapy

hiPSC-Neural Stem/Progenitor Cell Transplantation Therapy for Spinal Cord Injury

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