Title:The Interaction Network of MicroRNAs with Cytokines and Signaling
Pathways in Allergic Asthma
Volume: 11
Issue: 2
Author(s): Ali Farmanzadeh*, Durdi Qujeq and Tooba Yousefi
Affiliation:
- Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
Keywords:
Allergic asthma, microRNAs, cytokines, signaling pathways, inflammation, cytokines.
Abstract: Allergic asthma is a complicated disease that is affected by many factors. Numerous cytokines
and signaling pathways are attributed to the cause of asthma symptoms. MicroRNAs (miRNAs) are a
group of small non-coding single-stranded RNA molecules that are involved in gene silencing and posttranscriptional
regulation of gene expression by targeting mRNAs. In pathological conditions, altered
expression of microRNAs differentially regulates cytokines and signaling pathways and therefore, can be
the underlying reason for the pathogenesis of allergic asthma. Indeed, microRNAs participate in airway
inflammation via inducing airway structural cells and activating immune responses by targeting
cytokines and signaling pathways. Thus, to make a complete understanding of allergic asthma,
it is necessary to investigate the communication network of microRNAs with cytokines and signaling
pathways which is contributed to the pathogenesis of allergic asthma. Here, we shed light on this aspect
of asthma pathology by Summarizing our current knowledge of this topic.
