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Current Neuropharmacology

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ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

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Perspective

Potential Clinical Role of Prokineticin 2 (PK2) in Neurodegenerative Diseases

Author(s): Daniela Maftei, Tommaso Schirinzi, Nicola B. Mercuri, Roberta Lattanzi and Cinzia Severini*

Volume 20, Issue 11, 2022

Published on: 18 August, 2022

Page: [2019 - 2023] Pages: 5

DOI: 10.2174/1570159X20666220411084612

Abstract

The role of the immune system in neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD) has become clear in recent decades, as evidenced by the presence of activated microglia and astrocytes and numerous soluble mediators in the brain and peripheral tissues of affected patients. Among inflammatory mediators, chemokines play a central role in neuroinflammation due to their dual function as chemoattractants for immune cells and molecular messengers in crosstalk among CNS-resident cells. The chemokine Bv8/Prokineticin 2 (PK2) has recently emerged as an important player in many age-related and chronic diseases that are either neurodegenerative or systemic. In this perspective paper, we briefly discuss the role that PK2 and its cognate receptors play in AD and PD animal models and in patients. Given the apparent changes in PK2 blood levels in both AD and PD patients, the potential clinical value of PK2 either as a disease biomarker or as a therapeutic target for these disorders is discussed.

Keywords: Prokyneticin 2, neuroinflammation, Alzheimer’s disease, Parkinson’s disease, therapeutic targets, clinical biomarkers.

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