Biology and Natural History of Type 1 Diabetes Mellitus

Jenner   Chrystian Veríssimo   de Azevedo; Thales   Allyrio Araújo   de Medeiros Fernandes; Gilson   Aquino   Cavalcante; Iluska   Almeida Carneiro Martins   de Medeiros; Daniel   Carlos Ferreira   Lanza; Joselio   Maria Galvão   de Araújo; Fabiana   Lima   Bezerra; José   Veríssimo   Fernandes
doi:10.2174/1573396318666220409001955
Abstract

Type 1 diabetes mellitus is a clinical condition characterized by insufficient insulin production due to progressive loss of pancreatic islet β-cells mediated by an autoimmune response. This deregulation of the immune system is caused by the action of genetic, epigenetic, and environmental factors in varying combinations for each individual. Although the inflammation of the islets with immune cell infiltration, known as insulitis, is an important element in pathogenesis, other factors are necessary for disease initiation. Associations with variants of HLA and other genes related to immune system function, mainly haplotypes HLA-DR3-DQ2 and HLA-DR4-DQ8, are more evident. The influence of polymorphisms and epigenetic modifications, as well as the microbiome, is convincing proof of the existence of a complex interaction between genetic, immune, and environmental factors in the etiology and pathogenesis of this metabolic disorder. Loss of selftolerance to autoimmunity is a critical point in the development of the disease, and regulatory T cells play a key role in this process. Thus, any failure of these cells, either due to an insufficient number or altered expression of cytokines and transcription factors, may be the trigger for the onset of the disease. The protective action of regulatory T cells is controlled by gene expression that is modulated by epigenetic modifications, including the dysregulation of noncoding RNAs. This review takes an updated approach to the natural history of type 1 diabetes, focusing on the factors involved in the etiology and pathogenesis.
Keywords: Dysglycemia, diabetes mellitus, type 1 diabetes, autoimmune diabetes, juvenile diabetes, metabolic disease.
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Graphical Abstract

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DOI https://dx.doi.org/10.2174/1573396318666220409001955	Print ISSN 1573-3963
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Current Pediatric Reviews

Biology and Natural History of Type 1 Diabetes Mellitus

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