Title:Effects of Long-term Use of Proton Pump Inhibitors on Systemic Arterial
Stiffness and Pulse Wave Velocity
Volume: 20
Issue: 5
Author(s): Ufuk Kutluana*, Ecem Kutluana, Mehmet Alpua and Mert Özen
Affiliation:
- Faculty of Medicine, Pamukkale University, Internal Medicine and Gastroenterology Department, Denizli, Turkey
Keywords:
Proton pump inhibitors, cardiovascular disease, pulse wave velocity, arterial stiff, acid suppression therapy, H. pylori.
Abstract:
Background and Aim: Proton pump inhibitors (PPIs) are among the most widely prescribed
agents. Although PPIs are widely regarded as harmlesss, long-term use of PPIs (LTUPPI) can have the
potential to increase the risk of developing cardiovascular (CV) disease (CVD). Pulse wave velocity
(PWV) is a good indicator of arterial stiffness. Several studies show a relationship between LTUPPI and
CVD. However, the association between LTUPPI and PWV or arterial stiffness has not been reported.
Patients and Methods: Patients (n=64) with LTUPPI and controls (n=91) were included. PWV, glucose,
creatinine, total cholesterol, triglyceride, low-density lipoprotein cholesterol, cholesterol, highdensity
lipoprotein cholesterol, and magnesium levels were measured.
Results: In the LTUPPI group, PWV was greater than in controls (9.08±2.04 vs. 7.77±1.52 m/s, respectively,
p=0.01); 34.4% of patients and 8.8% of controls had PWV levels >10 m/s (p=0.000). Multiple logistic
regression analysis showed age (p<0.001) and LTUPPI (p=0.024) as predictors of elevated PWV.
Conclusion: PWV values are increased in patients with LTUPPI compared to controls independently of
conventional CV risk factors. Measurement of PWV and other arterial stiffness parameters in cases with
LTUPPI may be useful to predict possible CVD. Studies involving greater numbers are needed to confirm
these findings.
