Title:Identification of Potential of Drug-drug Interaction and its Affecting Factors:
A Cross-sectional Study Among Hospitalized Coronary Heart Disease
Patients
Volume: 17
Issue: 2
Author(s): Reny Rosmasari, Pramitha Esha*Albert Figueras
Affiliation:
- Department of Pharmacy Profession, Universitas Muhammadiyah Yogyakarta, Kasihan, Indonesia
Keywords:
Coronary heart disease, potential drug-drug interactions, cross-sectional study, drug-drug interaction, mortality, pharmacodynamics.
Abstract:
Background: Coronary Heart Disease (CHD) patients are at risk of suffering from drug interactions,
leading to a higher risk of mortality and morbidity among these patients. This study aims to
identify the potential drug-drug interactions (PDDIs) and CHD patients' related factors.
Methods: A cross-sectional study was performed among the CHD patients to identify the PDDIs from
2014 to 2017 at a Secondary Hospital. The PDDIs were categorized according to the interaction
mechanism, onset, severity, and documentation.
Results: Among 91 CHD patients, 151 PDDIs were identified consisting of pharmacokinetics mechanism
and delayed onset, 50.33%, and 83.44%, respectively. Furthermore, there was a correlation between
the number of PDDIs and the number of drugs (r = 0.496; p < 0.001).
Conclusion: This study revealed that the more the drugs were prescribed to CHD patients, the more
the PDDIs risk would occur. The regular monitoring of the CHD patient’s prescriptions is noteworthy
to avoid the PDDIs.
