Title:A Concise Review on Tyrosine Kinase Targeted Cancer Therapy
Volume: 17
Issue: 2
Author(s): Ashish Shah*, Chhagan Patel, Ghanshaym Parmar, Ashish Patel and Manav Jain
Affiliation:
- Department of Pharmacy, Sumandeep Vidyapeeth, Vadodara, Gujarat, India
Keywords:
Tyrosine kinase, types of receptors, tyrosine kinase inhibitors, cancer, small molecules, targeted therapy.
Abstract: Tyrosine Kinase (TK) is considered one of the important family members of the kinase
family due to its important role in various cellular processes like cell growth, cell differentiation,
apoptosis, etc. Mutation, overexpression, and dysfunction of tyrosine kinase receptors lead to the development
of malignancy; thus, they are considered one of the important targets for the development
of anti-cancer molecules. The tyrosine kinase family is majorly divided into two classes; receptor and
non-receptor tyrosine kinase. Both of the classes have an important role in the development of tumour
cells. Currently, more than 40 FDA-approved tyrosine kinase inhibitors are used to treat various types
of cancers. Tyrosine kinase inhibitors mainly block the phosphorylation of tyrosine residue of the corresponding
kinase substrate, so activation of downstream signalling pathways can be inhibited. The
promising results of tyrosine kinase inhibitors in solid tumours have revolutionized oncology research.
In this article, we summarized the role of some important members of the tyrosine kinase family in the
development and progression of tumour cells and the significance of tyrosine kinase inhibitors in the
treatment of various types of cancer.
