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Review Article

与EMT相关的lncRNAs在治疗耐药性中的作用及其作为生物标志物的应用

卷 29, 期 26, 2022

发表于: 10 May, 2022

页: [4574 - 4601] 页: 28

弟呕挨: 10.2174/0929867329666220329203032

价格: $65

摘要

癌症是世界第二大死因。最常见的癌症治疗方法是手术、放疗和化疗。耐药、上皮-间充质转化（EMT）和转移是当今癌症治疗的紧迫问题。越来越多的证据表明，耐药与EMT之间存在着密切的联系。的确，耐药癌细胞具有更强的EMT和侵袭能力。最近的研究表明，lncRNAs（长链非编码RNAs）是一种非编码转录本，在不同癌症的EMT、转移和耐药调控中发挥重要作用。然而，lncRNAs与EMT和耐药性之间的关系尚不清楚。这些作用可能通过多种信号通路发挥作用，如TGF-β、PI3K-AKT和Wnt/β-catenin。确定lncRNAs在这些途径和过程中的关键调控作用，将有助于开发新的靶向治疗方法。我们综述了与EMT和治疗耐药相关的lncRNAs的关键方面。我们关注lncRNAs与影响EMT和耐药的分子信号通路之间的串扰。此外，上述每种lncRNAs都可作为癌症的潜在诊断、预后和治疗耐药指标。然而，lncRNAs的临床应用研究仍存在一些挑战。

关键词: 长链非编码RNA，耐药，EMT, Wnt/β-catenin通路，PI3K-AKT通路，TGF-β通路，EMT相关lncRNAs，耐药，生物标志物。

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